Yuzu fruit itself is naturally gluten-free, as it’s a citrus fruit and does not contain any gluten proteins. However, when considering yuzu-flavored products or prepared foods containing yuzu, it’s important to check the ingredients list or with the manufacturer to ensure no gluten-containing additives have been used in processing.

Rich in vitamin C: Boosts immune system and acts as an antioxidant
Contains flavonoids: Provides anti-inflammatory and antioxidant properties
Source of limonene: May have cancer-fighting properties
Contains beta-carotene: Promotes eye health and skin health
Provides dietary fiber: Aids in digestion and promotes gut health
Contains essential oils: May have antimicrobial properties
Low in calories: Supports weight management
Contains potassium: Helps maintain healthy blood pressure
Rich in antioxidants: Helps protect cells from damage caused by free radicals
May help reduce stress and anxiety: The aroma of yuzu has been linked to stress reduction
Supports skin health: Its vitamin C content aids in collagen production
May have anti-diabetic properties: Some studies suggest it may help regulate blood sugar levels
Supports heart health: Its flavonoids may help improve circulation and reduce the risk of heart diseaseRemember that while yuzu has many potential health benefits, it should be consumed as part of a balanced diet and healthy lifestyle.
Individuals with citrus allergies: Yuzu is a citrus fruit and may cause allergic reactions in those sensitive to citrus.
People taking certain medications: Yuzu may interact with some medications, particularly those metabolized by the liver. Always consult a healthcare provider about potential interactions.
Those with gastroesophageal reflux disease (GERD) or acid reflux: The high acidity of yuzu may exacerbate symptoms.
Individuals with kidney problems: The high potassium content in yuzu might be a concern for those with kidney issues.
People with dental sensitivities: The acidic nature of yuzu can potentially erode tooth enamel or cause discomfort.
Those with skin sensitivities: Topical use of yuzu essential oil may cause skin irritation in some individuals.
Pregnant or breastfeeding women: While moderate consumption is likely safe, excessive intake should be avoided due to limited research on its effects.
Young children: Due to its strong flavor and acidity, yuzu might not be suitable for very young children.
Individuals preparing for certain medical tests: The compounds in yuzu might interfere with some diagnostic procedures.Always consult with a healthcare professional if you have any concerns about consuming yuzu, especially if you have pre-existing health conditions or are taking medications.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

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Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.