Is Fregola Gluten Free?
Fregola, also known as Sardinian couscous, is not gluten-free. It is made from semolina flour, which comes from durum wheat and contains gluten.

Source of complex carbohydrates: Provides sustained energy and helps maintain stable blood sugar levels.
Contains some dietary fiber: Supports digestive health and may help with feelings of fullness.
Low in fat: Can be part of a heart-healthy diet when consumed in moderation.
Provides some protein: Contributes to muscle maintenance and growth.
Source of B vitamins: Particularly thiamine (B1) and niacin (B3), which support energy metabolism.
Contains small amounts of minerals: Including iron, magnesium, and zinc, which play various roles in body functions.
Versatile ingredient: Can be used in many dishes, potentially increasing vegetable and lean protein intake when combined with these foods.
Gluten-free options available: For those with gluten sensitivities, some brands offer gluten-free fregola made from alternative grains.
May contribute to Mediterranean diet benefits: As part of a traditional Mediterranean eating pattern, which is associated with various health benefits.Remember that the overall health impact of fregola depends on how it’s prepared and what it’s served with. Pairing it with vegetables, lean proteins, and healthy fats can enhance its nutritional value.
People with celiac disease or non-celiac gluten sensitivity: Fregola is typically made from semolina wheat, which contains gluten.
Individuals with wheat allergies: As fregola is made from wheat, those with wheat allergies should avoid it.
People following a low-carb or ketogenic diet: Fregola is high in carbohydrates, which may not align with these dietary approaches.
Individuals with diabetes who need to carefully monitor their carbohydrate intake: The high carb content may affect blood sugar levels.
Those following a grain-free diet: Fregola is a grain-based food and should be avoided by people on grain-free diets.
People with specific digestive issues that are triggered by wheat or pasta products: Some individuals may experience discomfort after consuming wheat-based foods.
Anyone with a diagnosed durum wheat sensitivity: Fregola is typically made from durum wheat semolina.
Individuals following a paleo diet: As a grain-based food, fregola is not considered paleo-friendly.
Those with severe obesity who are on a medically supervised, very low-calorie diet: Fregola is calorie-dense and may not fit into such restricted meal plans.Remember, if you have any specific dietary concerns or health conditions, it’s always best to consult with a healthcare professional or registered dietitian before making significant changes to your diet.
Explore gluten management solutions like Tolerase® G.
What is Tolerase® G?
A new Approach for People with Gluten Sensitivity:
Explore the Science and Benefits of Tolerase® G.
Relief from Gluten Sensitivity
In the fight against gluten, there is a unique supplement that stands out: Little Helpers anti-gluten pills with 100% Tolerase® G.
This specific enzyme, Tolerase® G, a patented endopeptidase specific for proline, was developed by Royal DSM and has been scientifically proven to be effective in breaking down gluten residues ( 1) . Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP), an enzyme closely related to Tolerase® G, can break down gluten so effectively that it barely reaches the duodenum, potentially eliminating gluten toxicity ( 2) ( 3 ) .
On this page we explain why we are so enthusiastic about this supplement, supported by scientific research.

What is Gluten?
Gluten is a group of proteins found primarily in grains such as wheat, barley, and rye. These complex proteins give shape, strength, and texture to bread and other grain products. However, gluten is difficult to digest because it is rich in proline, a non-essential amino acid. This is why about 13% of the world’s population is sensitive to gluten in their diet (1).
How Tolerase® G Works
It is important to note that Tolerase G is designed to have optimal activity in the difficult conditions of the stomach. Its effectiveness on the digestion of gluten in the stomach and duodenum has been scientifically proven ( 1 ).
Studies have shown that a newly identified prolyl endoprotease derived from Aspergillus niger can effectively break down gluten proteins. This enzyme works optimally at a pH of 4–5, remains stable at pH 2, and is completely resistant to digestion by pepsin ( 2 ). Furthermore, research has shown that Aspergillus niger prolyl endoprotease (AN-PEP) accelerates the breakdown of gluten in the stomach so much that very little gluten reaches the duodenum ( 3 ). This suggests that co-administration of AN-PEP with a meal containing gluten could potentially eliminate gluten toxicity, allowing people to (occasionally) abandon their strict gluten-free diet ( 3 ).
100% Tolerase® G Anti-Gluten Pills

Unique Enzyme Solution
Discover how our 100% Tolerase® G pills help digest gluten and support your lifestyle in a clear video.
Little Helpers & Tolerase® G: Stronger Together in the Fight against Gluten.
At Little Helpers we are proud of our unique partnership with the producer of Tolerase® G DSM . Together we have spent 2.5 years of research and worked tirelessly to develop and perfect our gluten digestion pill, which contains 100% Tolerase® G.
Our shared commitment to quality and effectiveness has resulted in a product that is unmatched in the market. We have chosen to manufacture locally in Europe to ensure the highest quality standards and control.
Our pill has proven to be many times more effective than our competitors, and we offer it at the best price. We are convinced that our pill can make a difference for people who struggle with gluten sensitivity. That is why we encourage everyone to try it and experience the benefits for themselves!
The Only Effective Anti-Gluten Pills
Little Helpers Anti-Gluten Pills contain 100% Tolerase® G. Tolerase® G is the only enzyme on the market that has been scientifically proven to be effective enough to break down gluten in the stomach to the point where the body no longer reacts to it.

Frequently Asked Questions
Our Expert
Drs. Ilse van Asperen
Drs. Ilse van Asperen is a medical doctor specialising in orthomolecular therapy and nutritional coaching. With a background in public and clinical health research and management, she focuses on addressing the root causes of health issues through diet, gut health, and stress reduction. As a professional editor for Little Helpers, she reviews all gluten-free content to ensure accuracy, safety, and scientific credibility. More about me
Our Sources
The information on this page is based on reputable health and nutrition organisations, ensuring accuracy and reliability for anyone following a gluten-free diet. For further details, see the sources below.
Sources
Experiences of our customers
Disclaimer: We do our best to provide accurate gluten information, but errors can happen. If you spot a mistake or have concerns, please contact us so we can make it right.